Tetraspanins predict the prognosis and characterize the tumor immune microenvironment of glioblastoma
Abstract Glioblastoma (GBM) is the most aggressive and lethal primary brain tumor.Conventional treatments have not achieved breakthroughs in improving survival.Therefore, novel molecular targets and biomarkers need to be identified.As signal transduction docks on the cell membrane, tetraspanins (TSPANs) are associated with various tumors; however,